The prevalence of obesity is increasing dramatically throughout the Western world

These results have important implications for the clinical assessment of patients with combined obesity and airway obstruction.

Abbreviations: AN OVA = analysis ofvariance; Dlco = diffusing capacity of the lung for carbon monoxide; ERV = expiratory reserve volume; FRC = functional residual capacity; GOLD = Global Initiative for Chronic Obstructive Lung Disease; IC = inspiratory capacity; LLN = lower limit of normal; NW = normal weight; OB = obese; OW = overweight; Raw = airway resistance; RV = residual volume; sRaw = specific airway resistance; TLC = total lung capacity; UW = underweight; VC = vital capacity.

The prevalence of obesity is increasing dramatically throughout the Western world. It is well established that obesity can result in respiratory impairment and increased respiratory symptoms, even in individuals without airway obstruction. The main physiologic effects of simple obesity include reduced respiratory system compliance, increased work and oxygen cost of breathing, and increased peripheral airway closure. In a cohort of individuals without airway obstruction (prebronchodilator FEV/FVC > 90% predicted), Jones and Nzekwui confirmed an inverse relation between increasing BMI and static lung volume components. In that study, it was established that relatively small increases in BMI (ie, the overweight [OW] range) had profound effects on functional © 2011 American College of Chest Physicians. Reproduction of this article is prohibited without written permission from the American College of Chest Physicians residual capacity (FRC) and expiratory reserve volume (ERV).

The interaction between increasing BMI and lung volumes in individuals with underlying airway obstruction is less well established. Recent studies in asthma have indicated that the relation between BMI and lung volumes appears to be similar to that described in populations without airway obstruction. Information Viagra Canada is lacking on the effect of BMI on plethysmo-graphic lung volume measurements in patients with COPD. This information becomes important for accurate interpretation of pulmonary function tests in an ever-increasing number of patients in whom obesity and chronic airway obstruction coexist.

Posted in Obesity | No Comments »

Comments are closed.